|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India.
|
31774004 |
2020 |
|
Childhood Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India.
|
31774004 |
2020 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiplex CRISPR/Cas9 gene editing and somatic cell nuclear transfer were used to generate pigs carrying functional knockouts of GGTA1, CMAH, B4GALNT2 and SLA class I. Fibroblasts derived from one- to four-fold knockout animals, and from multi-transgenic cells (human CD46, CD55, CD59, HO1 and A20) with the four-fold knockout were used to examine the effects on human IgG and IgM binding or complement activation in vitro.
|
31591751 |
2020 |
|
Atypical Hemolytic Uremic Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Atypical hemolytic-uremic syndrome: recurrent phenotypic expression of a patient with MCP gene mutation combined with risk haplotypes.
|
30676336 |
2019 |
|
Atypical Hemolytic Uremic Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS).
|
30870849 |
2019 |
|
Hemolytic-Uremic Syndrome
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The pathogenic variant in CD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension.
|
30870849 |
2019 |
|
Measles
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additional correlates of protection and long-term immunity and new determinants/signatures of vaccine responsiveness such as specific CD46 and IFI44L genetic variants associated with neutralizing antibody titers after measles vaccination are under investigation.
|
30585753 |
2019 |
|
Measles
|
0.400 |
Biomarker
|
disease |
BEFREE |
GOS/MV-Edm remained the infectivity in murine cells that lack CD46.
|
31533779 |
2019 |
|
Hypertensive disease
|
0.110 |
Biomarker
|
group |
BEFREE |
The pathogenic variant in CD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension.
|
30870849 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, it overcomes antibody blocking of the BVDV receptor CD46, indicating that cell-to-cell transmission of the virus involves the engagement of coreceptors on the target cell.<b>IMPORTANCE</b> BVDV causes one of the most economically important viral infections for the cattle industry.
|
30404802 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, we demonstrate a CD46-dependent entry pathway of virus infection in trophoblasts, but not in fibroblasts, highlighting the complexity of CMV entry and identifying CD46 as an entry factor in congenital infection.
|
31221976 |
2019 |
|
Thrombotic Microangiopathies
|
0.070 |
GeneticVariation
|
group |
BEFREE |
The pathogenic variant in CD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension.
|
30870849 |
2019 |
|
Rheumatoid Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab (RTX) with depletion and time repopulation of such cells.
|
29037309 |
2019 |
|
Rheumatoid Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
• In this study, we evaluated the diagnostic accuracy of US and MRI for bone erosion in RA patients, neither MRI nor US showed perfect diagnostic test accuracy.• 1.5-T Signa system and the LOGIQ units both from General Electric© are the machine types of MRI and US with the greatest performance, respectively.• The 2nd MCP joint is the scanning position recommended during US test.• Different reference standards will greatly influence the judgment of the results.
|
31713730 |
2019 |
|
Kidney Failure, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS).
|
30870849 |
2019 |
|
Chronic kidney disease stage 5
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS).
|
30870849 |
2019 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Whether overexpression of TLX plays a role in glioma stem cell (GSC) proliferation and migration still remains largely unknown.
|
27881004 |
2019 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
The metacarpal head cartilage was positive for cartilage damage in 35.7% (148/414) of MCP joints in RA and in 43.6% (116/266) of MCP joints in OA patients.
|
30690561 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A total of 96 children with ALL undergoing therapy with MCP-841 protocol were screened for all the ten exons of TPMT, exon 2, exon 3 and intron 2 of ITPA using bidirectional sequencing.
|
30806759 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21.
|
31152776 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21.
|
31152776 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The transcriptional expression in peripheral white blood cells (WBCs) of CD46 and CD55 was investigated in 157 patients enrolled by the Validation of the Oxford Classification of IgAN group, looking for correlations with clinical and pathology features and estimated glomerular filtration rate (eGFR) modifications from renal biopsy to sampling.
|
29635535 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Rabbits were divided into sham, heart failure (model), MCP, and perindopril groups, respectively.
|
30967790 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Rabbits were divided into sham, heart failure (model), MCP, and perindopril groups, respectively.
|
30967790 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 96 children with ALL undergoing therapy with MCP-841 protocol were screened for all the ten exons of TPMT, exon 2, exon 3 and intron 2 of ITPA using bidirectional sequencing.
|
30806759 |
2019 |